The Science of Extrapolation
Says Dr. Happy Oncologist:
I am troubled BY the rhetoric you put forth that a) chemotherapy invariably yields a miserable existence while you're going through it, and b) that metastatic breast cancer is as grim a diagnosis as other metastatic disease. Life expectancy can often extend past a year depending on the situation, and there is definitely a tail on that distribution . . .
. . . Am I extremely cautious about treating someone that old? Certainly. But do I dismiss it out of hand? Definitely not. And when you show me any double blind RCT that includes patients with IDDM and CHF as comorbidities (saving you from having to, yes, extrapolate data based on your best clinical judgement), I'll eat my words.
Amen. A gracious smack down.